BULLETIN 11 (2010)

November 22, 2010

Your Health Bulletin is information from scientific literature to make sense of the right choices for your health.  It is a reminder to consider periodic check-ups of your spine, joint mechanics and appropriate exercise.  Maintenance is better than repair!


What you need to know to get well and stay well


Focus: Review of anti-inflammatory foods


- Review of gut microflora and its relationship to food intolerance, immunity     and not feeling well

- Review of saliva resistivity as indicator of gut (gastrointestinal) function

- Review of pain, exercise and inflammation

- Introduction to cholesterol and the cholesterol hypothesis originator Ancel Keys


I daily survey various news science reviews and although we have covered aspects of pain meds before I was quite taken by the stats on the use of acetaminophen and development of asthma. As you read you will see that about 40% of asthma today is suggested to be caused by the use of this common pain medication.


Consider that approximately 500 people per year die from asthma and about 3 million suffer from the condition in Canada — why would anyone want to live with asthma when there is a way of ridding yourself of it? That is if you are willing to make the right changes in your environment — what you breathe and eat. To overcome and manage such difficulty you have to have the desire to do so and the knowledge to do it. That is the focus of the Wednesday night Info Sessions. Hope to see you there!




ScienceDaily (Aug. 13, 2010) — New evidence linking the use of acetaminophen to development of asthma and eczema suggests that even monthly use of the drug in adolescents may more than double the risk of asthma in adolescents compared to those who used none at all; yearly use was associated with a 50 percent increase in the risk of asthma.


The research results will be published online on the American Thoracic Society’s Web site ahead of the print edition of the American Journal of Respiratory and Critical Care Medicine.


The study involved 300,000 13 and 14 year old children in 113 centers throughout 50 countries, asking them to quantify their use of acetaminophen (none, “medium” — at least once in the last year, or “high” — at least once in the last month) and their asthma, eczema and allergy symptoms.


There was a significant association between acetaminophen use and risk of asthma and eczema. For medium users the risk of asthma was 43 percent higher than non-users; high users had 2.51 times the risk of non-users. Similarly, the risk of rhinoconjunctivitis (allergic nasal congestion) was 38 percent higher for medium users and 2.39 times as great for high users compared to non-users. For eczema, the relative risks were 31 percent and 99 percent respectively.


In an earlier study from the United States, 13 and 14 year old children with asthma were randomized to take either acetaminophen or ibuprofen after a febrile illness. For those whose illness was respiratory, there was an increased risk of a subsequent outpatient visit for asthma.


Possible explanations include: Acetaminophen may have a systemic inflammatory effect, possibly increasing oxygen stress resulting from the depletion of glutathione-dependent enzymes, which may in turn lead to enhanced allergic immune responses. Furthermore, acetaminophen may suppress the immune response to, and prolong the symptomatic illness from, rhinovirus infections, which are a common cause of severe asthma exacerbations in childhood


Dr. Beasley and colleagues calculated “The overall population attributable risks for current symptoms of severe asthma were around 40 percent, suggesting they would be of major public health significance,” said Dr. Beasley. “Randomized controlled trials are now urgently required to investigate this relationship further and to guide the use of antipyretics, not only in children but in pregnancy and adult life.”




ScienceDaily (Nov. 5, 2009) – New research shows that the widely used pain reliever acetaminophen may be associated with an increased risk of asthma and wheezing in both children and adults exposed to the drug.


Researchers from the University of British Columbia, Vancouver, BC, Canada, conducted a systematic review and meta analysis of 19 clinical studies (total subjects=425,140) that compared the risk of asthma or wheezing with acetaminophen exposure.


Furthermore, results showed a slight increase in the risk of asthma and wheezing with prenatal use of acetaminophen by mothers




ScienceDaily (Feb. 4, 2010) – Children who were exposed to acetaminophen prenatally were more likely to have asthma symptoms at age five in a study of 300 African-American and Dominican Republic children living in New York City. Building on prior research showing an association between both prenatal and postnatal acetaminophen and asthma, this is the first study to demonstrate a direct link between asthma and an ability to detoxify foreign substances in the body. The findings were published this week in the journal Thorax.


The children whose mothers had taken acetaminophen were more likely to wheeze, visit the emergency room for respiratory problems, and develop allergy symptoms, compared to those children whose mothers did not take acetaminophen.




Anybody who lives with asthma does not have to if they are willing to stop eating pro inflammatory foods and clean up the air in their living space.



Vigorous exercise reduces breast cancer risk in African-American women

October 2, 2010


Vigorous exercise of more than two hours per week reduces the risk of developing breast cancer in postmenopausal African-American women by 64 percent, compared to women of the same race who do not exercise, according to researchers at Georgetown Lombardi Comprehensive Cancer Center.


Results were presented at the Third AACR Conference on The Science of Cancer Health Disparities, held Sept. 30 to Oct. 3, 2010.


“People often want to know what they can do to reduce their risk of disease, and we have found that just two or more hours of vigorous activity per week can made a difference in one’s risk of developing breast cancer,” said the lead researcher Vanessa Sheppard, Ph.D., a cancer control scientist and assistant professor in the department of oncology at the Lombardi Comprehensive Cancer Center.


In this study, more than two hours of aerobics, running or similar activity over the span of a week counted as vigorous activity.


Women who exercised vigorously for more than two hours a week in the past year had a 64 percent reduced risk of breast cancer compared to women who did not exercise. Women who engaged in moderate exercise, like walking, had a 17 percent reduced risk, compared to women who were sedentary.

Comment: I would suggest that vigorous exercise would reduce the risk of the process of cancer in general. This would be due to the fact that out of breath exercise causes the release of muscle derived interlukin-6 which acts as an anti-inflammatory.



This exercise aids the mechanical function of the low back and body movement in general, and should be part of the group of exercises that you do to prevent back pain. If you have not been shown this exercise ask next time you are in the office. —– Pick a spot on the wall to look at about 5 ft. plus from the wall. Stand on one foot without shoes on and the other leg out to 90o and bent at the knee. Place arms by your side with eyes open, once you have good balance then close your eyes and try to maintain balance on 1 foot for at least 10 seconds. Try to do this exercise a total of 5 minutes daily total time, that is, don’t do the exercise all at once separate it throughout the day. One side will be easier than the other but if you find yourself falling easily you should stand in a corner of the room so you can catch yourself if you fall. The more you practice this the easier it will become and the better the low back mechanics.


See you in the office— maintenance is better than repair





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